Hydroxylamine → HCID 178446084, compound

HRID 2355255Notes

Reaction equation

HRID 2355255 reaction equation
[NH2:1][OH:2].[C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[N:10]([CH2:14][CH2:15][C:16]([NH:19][CH2:20][C@@H:21]([C:23]1[CH:24]=[C:25]([NH:29][S:30]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)(=[O:32])=[O:31])[CH:26]=[CH:27][CH:28]=1)[OH:22])([CH3:18])[CH3:17])[CH:9]=[CH:8]2)#[N:4]>C(O)C>[C:33]1([S:30]([NH:29][C:25]2[CH:24]=[C:23]([C@@H:21]([OH:22])[CH2:20][NH:19][C:16]([CH3:17])([CH3:18])[CH2:15][CH2:14][N:10]3[C:11]4[C:7](=[CH:6][C:5]([C:3]([NH:1][OH:2])=[NH:4])=[CH:13][CH:12]=4)[CH:8]=[CH:9]3)[CH:28]=[CH:27][CH:26]=2)(=[O:32])=[O:31])[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1

Participants

4

Reactant 2

HCID 787HydroxylamineHCID 58875107HCID 58875107, compound

Product 1

HCID 178446084HCID 178446084, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydroxylamine (600 μl) is added to a solution of N-(3-{(R)-2-[3-(5-cyano-indol-1-yl)-1,1-dimethyl-propylamino]-1-hydroxy-ethyl}-phenyl)-benzenesulphonamide (Example 1) (170 mg, 0.34 mmol) in 5 ml of ethanol. The reaction mixture is refluxed for 5 hours. Then the solvent is eliminated in vacuo.

Workup

  1. temperatureThe reaction mixture is refluxed for 5 hours

Sources & evidence

ORD record
ord-b83f26b9b60b43d8bd1779cea54f3105
Source dataset
uspto-grants-2010_07
Patent number
US07754756B2

Reaction notes

Loading…