Hydrochloric Acid → HCID 67192795, compound

HRID 2355345Notes

Reaction equation

HRID 2355345 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][O:6][CH:7]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[F:27])[CH:8]1[CH2:13][CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9]1.[ClH:28]>O1CCOCC1>[ClH:28].[CH3:1][O:2][CH2:3][CH2:4][CH2:5][O:6][CH:7]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[F:27])[CH:8]1[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59382867HCID 59382867, compound

Product 1

HCID 67192795HCID 67192795, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-Butyl 3-((3-methoxypropoxy)(2-fluorophenyl)methyl)piperidine-1-carboxylate (28.0 mg, 0.07 mmol) was dissolved in 4 N HCl in dioxane. The resulting solution was stirred at rt until no starting material was left (˜30 min). The solvent was removed in vacuo to give 3-((3-methoxypropoxy)(2-fluorophenyl)methyl)piperidine hydrochloride as an oil. MS ESI+ve m/z 282 (M+1).

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-1a3700723ce44203b71e74aa43846613
Source dataset
uspto-grants-2010_07
Patent number
US07754737B2

Reaction notes

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