Pentane → HCID 178506689, compound

HRID 2355382Notes

Reaction equation

HRID 2355382 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1Br.[Li:16]C(C)(C)C.CCCCC>C1COCC1>[F:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][CH:15]=1)[O:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[Li:16]

Participants

5

Reactant 3

HCID 8003PentaneHCID 184235101-Bromo-2-(3-fluorophenoxy)benzeneHCID 178418306HCID 178418306, compound

Product 1

HCID 178506689HCID 178506689, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
-70 °C

Procedure

To a stirred solution of 1-(3-fluorophenoxy)-2-bromobenzene (1.27 g, 4.75 mmol) in THF (10 mL) at −70° C. was added 1.7 M t-BuLi in pentane (5.6 mL, 9.50 mmol) dropwise to keep the temperature below −70° C. The resulting solution was stirred at −70° C. for 30 min, and used for the next step directly.

Workup

  1. customthe temperature below −70° C

Sources & evidence

ORD record
ord-1df3df6ca70f4bd7861dc075e09aec17
Source dataset
uspto-grants-2010_07
Patent number
US07754737B2

Reaction notes

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