Ammonium Acetate → HCID 67082112, compound

HRID 2355761Notes

Reaction equation

HRID 2355761 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:17])[CH2:10][C:11](=O)[C:12]([F:15])([F:14])[F:13])=[CH:4][C:3]=1[C:18]1[S:19][C:20]([CH3:24])=[C:21]([CH3:23])[N:22]=1.C([O-])(=O)C.[NH4+:29]>C(OCC)(=O)C>[NH2:29][C:11]([C:12]([F:15])([F:14])[F:13])=[CH:10][C:9]([NH:8][C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([C:18]2[S:19][C:20]([CH3:24])=[C:21]([CH3:23])[N:22]=2)[CH:4]=1)=[O:17]

Participants

4

Reactant 2

HCID 517165Ammonium AcetateHCID 86602838HCID 86602838, compound

Product 1

HCID 67082112HCID 67082112, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

A mixture of N-[4-chloro-3-(4,5-dimethyl-1,3-thiazol-2-yl)phenyl]-4,4,4-trifluoro-3-oxobutaneamide (3.80 g) and ammonium acetate (6.22 g) in 35 ml of ethyl acetate is refluxed for 7 hours, then cooled to room temperature and diluted with ethyl acetate (70 ml). The mixture is washed once with water and once with brine, then dried over sodium sulphate and concentrated under vacuum.

Workup

  1. temperatureis refluxed for 7 hours
  2. washThe mixture is washed once with water and once with brine
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-3f391d27c85c4482baafa1f04ec0d60e
Source dataset
uspto-grants-2010_07
Patent number
US07754880B2

Reaction notes

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