Tert-butyl 4-(4-hydroxy-4-phenylpiperidin-1-yl)benzoate → HCID 22730374, compound

HRID 2356139Notes

Reaction equation

HRID 2356139 reaction equation
[OH:1][C:2]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:7][CH2:6][N:5]([C:8]2[CH:20]=[CH:19][C:11]([C:12]([O:14]C(C)(C)C)=[O:13])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1>C(O)(C(F)(F)F)=O>[OH:1][C:2]1([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:3][CH2:4][N:5]([C:8]2[CH:20]=[CH:19][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=2)[CH2:6][CH2:7]1

Participants

3

Reactant 1

HCID 22730002Tert-butyl 4-(4-hydroxy-4-phenylpiperidin-1-yl)benzoate

Product 1

HCID 22730374HCID 22730374, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A solution of Example 493A (0.32 g, 0.91 mmol) in TFA (2 mL) at room temperature was stirred for 1 hour, and concentrated. The concentrate was azeotropically distilled with toluene three times and dried to provide the desired product. MS (ESI(+)) m/e 298 (M+H)+.

Workup

  1. concentrationconcentrated
  2. distillationThe concentrate was azeotropically distilled with toluene three times
  3. customdried

Sources & evidence

ORD record
ord-eedf2c4dce524f538bffda8eb99cadcb
Source dataset
uspto-grants-2010_07
Patent number
US07754886B2

Reaction notes

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