1-Propanol → HCID 68456514, compound

HRID 2356245Notes

Reaction equation

HRID 2356245 reaction equation
[Na].[CH2:2]([OH:5])[CH2:3][CH3:4].Cl[C:7]1[N:12]=[N:11][C:10]([NH2:13])=[CH:9][C:8]=1[CH3:14]>O>[CH3:14][C:8]1[CH:9]=[C:10]([NH2:13])[N:11]=[N:12][C:7]=1[O:5][CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 10311-PropanolHCID 5360545Sodium2×HCID 123536636-Chloro-5-methylpyridazin-3-amine

Product 1

HCID 68456514HCID 68456514, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Sodium (40 mg) was added to stirred propanol (4 g). After the sodium had dissolved, 6-chloro-5-methylpyridazin-3-amine (200 mg) was added and the mixture was heated to 155° in a glass pressure vessel with magnetic stirring for 24 h. The cooled reaction mixture was diluted with water and extracted with chloroform (3×50 mL). The combined extracts were dried (sodium sulfate) and evaporated to afford crude 5-methyl-6-propyoxypyridazin-3-amine.

Workup

  1. temperaturethe mixture was heated to 155° in a glass pressure vessel
  2. customThe cooled reaction mixture
  3. extractionextracted with chloroform (3×50 mL)
  4. dry with materialThe combined extracts were dried (sodium sulfate)
  5. customevaporated

Sources & evidence

ORD record
ord-b4c9e4c0c76c4f2280cd3aa89a1c31f3
Source dataset
uspto-grants-2010_07
Patent number
US07759349B2

Reaction notes

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