反应详情

温度

50 °C

To a solution of phenylmethyl 2-(2,5-dioxo-3-benzylimidazolidinyl)acetate (3.42 g, 10.0 mmol) in THF—H2O (3:1, 40 ml) was added lithium hydroxide monohydrate (0.85 g, 20.0 mmol). After stirring the mixture at 50° C. for 6 hours, the reaction mixture was alkalized with saturated aqueous sodium hydrogen carbonate solution and washed with ethyl acetate. The aqueous phase was acidified with diluted hydrochloric acid and extracted with ethyl acetate. The organic phase was washed with brine, dried over anhydrous magnesium sulfate, filtered and evaporated under reduced pressure. The residue was recrystallized with ethyl acetate and filtered off to give 2-(2,5-dioxo-3-benzylimidazolidinyl)acetic acid (1.28 g).

1. washwashed with ethyl acetate
2. extractionextracted with ethyl acetate
3. washThe organic phase was washed with brine
4. dry with materialdried over anhydrous magnesium sulfate
5. filtrationfiltered
6. customevaporated under reduced pressure
7. customThe residue was recrystallized with ethyl acetate
8. filtrationfiltered off