Potassium Carbonate → 4-Chloro-1-{[(4-chloro-2-fluorophenyl)methyl]oxy}-2-iodobenzene

HRID 2356610Notes

Reaction equation

HRID 2356610 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([I:9])[CH:3]=1.[Cl:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15]Br)=[C:13]([F:19])[CH:12]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:15][C:14]2[CH:17]=[CH:18][C:11]([Cl:10])=[CH:12][C:13]=2[F:19])=[C:4]([I:9])[CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 6202344-Chloro-2-iodophenolHCID 27365514-Chloro-2-fluorobenzyl bromide

Product 1

HCID 247536874-Chloro-1-{[(4-chloro-2-fluorophenyl)methyl]oxy}-2-iodobenzene

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

As for Reaction 1, using 84.87 g 4-chloro-2-iodophenol, 76 g 4-chloro-2-fluorobenzyl bromide and 92 g potassium carbonate in 900 ml acetone. Yield 129.36 g. Identical by TLC with product of Reaction 1.

Workup

  1. customAs for Reaction 1
  2. customIdentical by TLC with product of Reaction 1

Sources & evidence

ORD record
ord-d74ff76d7d5c4a4dae6850e515f5d686
Source dataset
uspto-grants-2010_07
Patent number
US07759369B2

Reaction notes

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