Water → 1-(Pyrimidin-2-yl)ethanone oxime

HRID 2356744Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2356744
[C:1]([C:4]1[N:9]=[CH:8][CH:7]=[CH:6][N:5]=1)(=O)[CH3:2].Cl.[NH2:11][OH:12].C(N(CC)CC)C.O>C(O)C>[C:1](=[N:11][OH:12])([C:4]1[N:9]=[CH:8][CH:7]=[CH:6][N:5]=1)[CH3:2]

Komponenten

6

Edukt 4

HCID 962WaterHCID 8471TriethylamineHCID 443297Hydroxyamine hydrochlorideHCID 116079091-(Pyrimidin-2-yl)ethan-1-one

Produkt 1

HCID 1362473411-(Pyrimidin-2-yl)ethanone oximeAusbeute 136,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 2-acetylpyrimidine (2.90 g), hydroxylamine hydrochloride (2.48 g) and triethylamine (5.3 ml) in ethanol (40 ml) was stirred at room temperature overnight. The reaction mixture was poured into water, and extracted with methylene chloride. The organic layer was washed with a saturated aqueous ammonium sulfate solution and brine, dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure to obtain 2-acetylpyrimidine oxime (4.44 g) as colorless powder.

Aufarbeitung

  1. extractionextracted with methylene chloride
  2. washThe organic layer was washed with a saturated aqueous ammonium sulfate solution and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customthe solvent was removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-901db3aae7ad4ed3b3e5ffcaf4d219f5
Quelldatensatz
uspto-grants-2010_07
Patentnummer
US07759373B2

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