Hydrochloric Acid → HCID 67548603, compound

HRID 2356754Notes

Reaction equation

HRID 2356754 reaction equation
[O:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[C:7]([C:10]3[O:14]C=[N:12][C:11]=3C(OC)=O)[CH:8]=[CH:9][C:2]1=2.[ClH:19]>CO.O1CCCC1>[ClH:19].[NH2:12][CH2:11][C:10]([C:7]1[CH:8]=[CH:9][C:2]2[O:1][CH:5]=[CH:4][C:3]=2[CH:6]=1)=[O:14]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 67546943HCID 67546943, compound

Product 1

HCID 67548603HCID 67548603, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a solution of the crude product of methyl 5-(5-benzo[b]furyl)oxazol-4-carboxylate (1.14 g) in methanol (20 ml) and tetrahydrofuran (5 ml) was added conc. hydrochloric acid (8 ml), and the mixture was stirred overnight. The reaction mixture was concentrated under reduced pressure and the resulting residue was triturated with methanol-diethyl ether-acetone to obtain 5-(aminoacetyl)benzo[b]furan hydrochloride (600 mg).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe resulting residue was triturated with methanol-diethyl ether-acetone

Sources & evidence

ORD record
ord-9ca83b73efa54803996a111eeb19603b
Source dataset
uspto-grants-2010_07
Patent number
US07759373B2

Reaction notes

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