Hydrochloric Acid → 6-(Dimethylamino)methylnicotinic acid hydrochloride

HRID 2356763Notes

Reaction equation

HRID 2356763 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11]C)=[O:10])=[CH:7][N:6]=1)[CH3:3].[ClH:15]>>[ClH:15].[CH3:3][N:2]([CH2:4][C:5]1[CH:14]=[CH:13][C:8]([C:9]([OH:11])=[O:10])=[CH:7][N:6]=1)[CH3:1]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 57573795Methyl 6-(dimethylamino)methylnicotinate

Product 1

HCID 675481076-(Dimethylamino)methylnicotinic acid hydrochloride

Procedure

A mixture of methyl 6-(dimethylamino)methylnicotinate (256 mg) and 10N hydrochloric acid was refluxed overnight. After cooling, the reaction mixture was concentrated under reduced pressure to obtain 6-(dimethylamino)methylnicotinic acid hydrochloride (329 mg) as colorless powder.

Workup

  1. temperaturewas refluxed overnight
  2. temperatureAfter cooling
  3. concentrationthe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-6b09a24c70d348d490a60adfd7a79b57
Source dataset
uspto-grants-2010_07
Patent number
US07759373B2

Reaction notes

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