Hydrochloric Acid → HCID 67152091, compound

HRID 2356821Notes

Reaction equation

HRID 2356821 reaction equation
[CH3:1][N:2]([C:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([N+:25]([O-])=O)=[CH:21][CH:20]=2)=[CH:15][CH:14]=1)=[O:12])[C@H:3]([C:7]([O:9][CH3:10])=[O:8])[CH:4]([CH3:6])[CH3:5].Cl>C(O)C.[Fe]>[NH2:25][C:22]1[CH:21]=[CH:20][C:19]([C:16]2[CH:17]=[CH:18][C:13]([C:11]([N:2]([CH3:1])[C@H:3]([C:7]([O:9][CH3:10])=[O:8])[CH:4]([CH3:6])[CH3:5])=[O:12])=[CH:14][CH:15]=2)=[CH:24][CH:23]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 59385241HCID 59385241, compound

Product 1

HCID 67152091HCID 67152091, compoundYield 76%

Reagents, catalysts & solvents 2

HCID 23925IronCatalystHCID 702EthanolSolvent

Procedure

To a solution of methyl N-methyl-N-[(4′-nitro-1,1′-biphenyl-4-yl)carbonyl]-L-valinate (0.70 g, 1.9 mmol) in 85% ethanol (20 mL) was added iron powder (1.05 g, 18.9 mmol) and 2N aqueous HCl solution (0.41 mL). The resulting mixture was heated at reflux for 2 h. The mixture was then filtered through a pad of Celite® and concentrated under reduced pressure. The residue was dissolved in methylene chloride, washed with water and brine, dried (Na2SO4) and concentrated under reduced pressure to afford methyl N-[(4′-amino-1,1′-biphenyl-4-yl)carbonyl]-N-methyl-L-valinate (0.49 g, 76%). 1H NMR (400 MHz, CD3OD) δ 0.85 (dd, 3H), 1.06 (dd, 3H), 2.35 (m, 1H), 3.02 (d, 3H), 3.75 (d, 3H), 4.05 (d, 0.5H), 4.78 (d, 0.5H), 6.78 (d, 2H), 7.42 (m, 4H), 7.63 (d, 2H); LC-MS m/z 341.2 (MH+), retention time 2.37 minutes.

Workup

  1. temperatureThe resulting mixture was heated
  2. temperatureat reflux for 2 h
  3. filtrationThe mixture was then filtered through a pad of Celite®
  4. concentrationconcentrated under reduced pressure
  5. dissolutionThe residue was dissolved in methylene chloride
  6. washwashed with water and brine
  7. dry with materialdried (Na2SO4)
  8. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-249ea6993d0b493a90943b7cadaffc72
Source dataset
uspto-grants-2010_07
Patent number
US07759376B2

Reaction notes

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