Bromocyclopentane → HCID 22319193, compound

HRID 2356894Notes

Reaction equation

HRID 2356894 reaction equation
[Br:1][C:2]1[C:3](=[O:14])[NH:4][CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH:7]=1.Br[CH:16]1[CH2:20][CH2:19][CH2:18][CH2:17]1.C(=O)([O-])[O-].[K+].[K+]>>[Br:1][C:2]1[C:3](=[O:14])[N:4]([CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)[CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 8728BromocyclopentaneHCID 11430Potassium CarbonateHCID 223190525'-Bromo[2,3'-bipyridin]-6'(1'H)-one

Product 1

HCID 22319193HCID 22319193, compoundYield 19.9%

Procedure

2.00 g of 3-bromo-5-(2-pyridyl)-1,2-dihydropyridin-2-one as the stock material was N-alkylated by the normal method with 5.94 g of bromocyclopentane and 5.50 g of potassium carbonate, to obtain 506 mg of 3-bromo-1-cyclopentyl-5-(2-pyridyl)-1,2-dihydropyridin-2-one, 150 mg of which was treated in accordance with the method for Example 32, to obtain 120 mg of the subject compound.

Sources & evidence

ORD record
ord-785875300f984d048ac97986b4a35959
Source dataset
uspto-grants-2010_07
Patent number
US07759367B2

Reaction notes

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