Lithium Hydroxide → HCID 11556344, compound

HRID 2356937Notes

Reaction equation

HRID 2356937 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C[O:9][C:10](=[O:44])[CH2:11][NH:12][CH2:13][C:14](=[O:43])[NH:15][C:16]1[CH:21]=[C:20]([N:22]2[C:26](=[O:27])[C:25]([CH3:29])([CH3:28])[N:24]([CH2:30][C:31]3[CH:36]=[CH:35][N:34]=[CH:33][CH:32]=3)[C:23]2=[O:37])[CH:19]=[CH:18][C:17]=1[O:38][C:39]([F:42])([F:41])[F:40].[OH-].[Li+]>O1CCOCC1.O>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH3:28][C:25]1([CH3:29])[C:26](=[O:27])[N:22]([C:20]2[CH:19]=[CH:18][C:17]([O:38][C:39]([F:40])([F:41])[F:42])=[C:16]([NH:15][C:14]([CH2:13][NH:12][CH2:11][C:10]([OH:44])=[O:9])=[O:43])[CH:21]=2)[C:23](=[O:37])[N:24]1[CH2:30][C:31]1[CH:32]=[CH:33][N:34]=[CH:35][CH:36]=1

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 11534695HCID 11534695, compound

Product 1

HCID 11556344HCID 11556344, compound

Reagents, catalysts & solvents 1

HCID 218864351,4-Dioxane--water (1/1)Solvent

Conditions

Temperature
50 °C

Procedure

100 mg (0.16 mmol) ({[5-(4,4-Dimethyl-2,5-dioxo-3-pyridin-4-ylmethyl-imidazolidin-1-yl)-2-trifluoromethoxy-phenylcarbamoyl]-methyl}-amino)-acetic acid methyl ester trifluoro acetate were dissolved in 5 ml dioxane/water (9/1) and treated with 9.3 mg (0.39 mmol) lithium hydroxide. After stirring for 1H at 50° C., the solvent was evaporated and the residue was purified by preparative HPLC. (C18 reversed phase column, elution with a water (0.1% trifluoracetic acid)/acetonitrile gradient) Yield: 10 mg.

Workup

  1. customthe solvent was evaporated
  2. customthe residue was purified by preparative HPLC
  3. washphase column, elution with a water (0.1% trifluoracetic acid)/acetonitrile gradient) Yield: 10 mg

Sources & evidence

ORD record
ord-bbc7432cb536403e8bb14c0acf4114b2
Source dataset
uspto-grants-2010_07
Patent number
US07759379B2

Reaction notes

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