Hydrochloric Acid → HCID 86617223, compound

HRID 2356947Notes

Reaction equation

HRID 2356947 reaction equation
C([O:3][CH:4](OCC)[CH2:5][O:6][C:7]1[CH:8]=[C:9]([N:15]2[C:19](=[O:20])[C:18]([CH3:22])([CH3:21])[N:17]([CH2:23][C:24]3[C:33]4[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=4)[N:27]=[CH:26][CH:25]=3)[C:16]2=[O:34])[CH:10]=[CH:11][C:12]=1[O:13][CH3:14])C.Cl.C1(C)C=CC=CC=1>O1CCOCC1>[CH3:21][C:18]1([CH3:22])[C:19](=[O:20])[N:15]([C:9]2[CH:10]=[CH:11][C:12]([O:13][CH3:14])=[C:7]([CH:8]=2)[O:6][CH2:5][CH:4]=[O:3])[C:16](=[O:34])[N:17]1[CH2:23][C:24]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[N:27]=[CH:26][CH:25]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 23110281HCID 23110281, compound

Product 1

HCID 86617223HCID 86617223, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
80 °C

Procedure

410 mg 3-[3-(2,2-Diethoxy-ethoxy)-4-methoxy-phenyl]-5,5-dimethyl-1-quinolin-4-ylmethyl-imidazolidine-2,4-dione were dissolved in 8 ml 1,4-dioxane and 2.05 ml of an aqueous 1 N solution of hydrochloric acid were added. The mixture was stirred for 2 hours at 80° C. Removal of the solvent under reduced pressure yielded a white solid, which was coevaporated twice with toluene. Yield: 340 mg

Workup

  1. customRemoval of the solvent under reduced pressure
  2. customyielded a white solid, which

Sources & evidence

ORD record
ord-291898b24d0c46489359c5e3605e9ed9
Source dataset
uspto-grants-2010_07
Patent number
US07759379B2

Reaction notes

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