Imidazole → HCID 277395, compound

HRID 2357419Notes

Reaction equation

HRID 2357419 reaction equation
[C:1]1([C:7](=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([O:19][CH3:20])[CH:13]=2)C(O)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O-])(O)=O.[Na+].N1C=CN=C1>>[OH:18][C:15]1[CH:16]=[CH:17][C:12]([CH:11]=[CH:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:13][C:14]=1[O:19][CH3:20]

Participants

4

Reactant 3

HCID 795ImidazoleHCID 516892Sodium BicarbonateHCID 53411296α-[(4-Hydroxy-3-methoxyphenyl)methylene]benzeneacetic acid

Product 1

HCID 277395HCID 277395, compoundYield 88%

Procedure

A mixture of α-phenyl-4-hydroxy-3-methoxy cinnamic acid (0.0083 mol), NaHCO3 (10%, 5 mL), imidazole (2 mL) and polyethylene glycol (15 mL) were taken in a 250 mL iodine flask fitted with loose funnel at the top. The flask was shaken well and placed inside the microwave oven and irradiated (900 W) for 8 minutes in parts. After completion of reaction, the reaction mixture was worked (yield 88%) as in example I. Spectral data as given in example I.

Workup

  1. customwere taken in a 250 mL iodine flask
  2. customfitted with loose funnel at the top
  3. customirradiated (900 W) for 8 minutes in parts
  4. customAfter completion of reaction

Sources & evidence

ORD record
ord-1d020932b8c64380a0bfd91deba6906f
Source dataset
uspto-grants-2010_07
Patent number
US07759527B2

Reaction notes

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