Sodium Bicarbonate → HCID 277395, compound

HRID 2357420Notes

Reaction equation

HRID 2357420 reaction equation
[C:1]1([C:7](=[CH:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([O:19][CH3:20])[CH:13]=2)C(O)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C([O-])(O)=O.[Na+]>C(O)CO>[OH:18][C:15]1[CH:16]=[CH:17][C:12]([CH:11]=[CH:7][C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:13][C:14]=1[O:19][CH3:20]

Participants

4

Reactant 2

HCID 516892Sodium BicarbonateHCID 53411296α-[(4-Hydroxy-3-methoxyphenyl)methylene]benzeneacetic acid

Product 1

HCID 277395HCID 277395, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 174Ethylene GlycolSolvent

Procedure

A mixture of α-phenyl-4-hydroxy-3-methoxy cinnamic acid (0.0083 mol), NaHCO3 (10%, 5 mL) methylimidazole (2 mL) and ethylene glycol (15 mL) were taken in a 250 mL round bottom flask fitted with reflux condenser. The flask was shaken well and placed on the heating mental and refluxed for 12 h. After completion of reaction, the reaction mixture was worked (yield 69%) as in example I. Spectral data as given in example I.

Workup

  1. customwere taken in a 250 mL round bottom flask
  2. customfitted
  3. temperaturewith reflux condenser
  4. temperaturerefluxed for 12 h
  5. customAfter completion of reaction

Sources & evidence

ORD record
ord-8b61fdcc35c14f428d771cb35d959ba4
Source dataset
uspto-grants-2010_07
Patent number
US07759527B2

Reaction notes

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