Hydrochloric Acid → HCID 10481291, compound

HRID 2357460Notes

Reaction equation

HRID 2357460 reaction equation
[CH3:1][N:2]([CH3:35])[C:3]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([N:12]2[CH2:17][CH:16]=[C:15]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:27][CH3:28])[CH:25]=4)[NH:20][CH:19]=3)[CH2:14][CH2:13]2)=[O:11])[CH2:5][CH2:4]1.[ClH:36]>C(O)C>[ClH:36].[CH3:35][N:2]([CH3:1])[C:3]1([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH2:8][CH2:7][C:6](=[CH:9][C:10]([N:12]2[CH2:13][CH:14]=[C:15]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[C:24]([O:27][CH3:28])[CH:25]=4)[NH:20][CH:19]=3)[CH2:16][CH2:17]2)=[O:11])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 10481292HCID 10481292, compound

Product 1

HCID 10481291HCID 10481291, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

2-(4-dimethylamino-4-phenylcyclohexylidene)-1-[4-(5-methoxy-1H-indol-3-yl)-3,6-dihydro-2H-pyridine-1-yl]-ethanone (252 mg, 0.536 mmole) was suspended in ethanol (20 ml) and 5M isopropanolic hydrochloric acid (0.214 ml, 1.07 mmole) was added. The hydrochloride precipitated out from the clear solution and after 1 hour was isolated as a colourless solid (222 mg, 82%) with an m.p. of 175°-178° C. (Example 28).

Workup

  1. customThe hydrochloride precipitated out from the clear solution and after 1 hour

Sources & evidence

ORD record
ord-b98dfbc9c74b4082a208f80f463f303e
Source dataset
uspto-grants-2010_07
Patent number
US07759385B2

Reaction notes

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