反应详情

温度

180 °C

A mixture of 6-bromo-1-chlorophthalazine (0.12 g, 0.5 mmol), 1-methylpiperazine (0.11 mL, 1.0 mmol) and potassium carbonate (0.07 g, 0.5 mmol) in ACN (5 mL) was added to a glass microwave reaction vessel. The reaction mixture was stirred and heated in a Smith Synthesizer® microwave reactor (Personal Chemistry, Inc., Upssala, Sweden) at 180° C. for 20 min. The mixture was concentrated in vacuo, and was purified by flash chromatography (silica gel) eluting with 2% 2 M ammonia in methanol/dichloromethane to 6% 2 M ammonia in MeOH/D)CM to give 6-bromo-1-(4-methylpiperazin-1-yl)phthalazine as yellow solid. MS (ES+): 307, 309 (M+H)+.

1. additionwas added to a glass microwave reaction vessel
2. concentrationThe mixture was concentrated in vacuo
3. customwas purified by flash chromatography (silica gel)
4. washeluting with 2% 2 M ammonia in methanol/dichloromethane to 6% 2 M ammonia in MeOH/D)CM