反应详情

温度

180 °C

A mixture of 6-bromo-1-chlorophthalazine (Example 1, 0.12 g, 0.5 mmol), 1-methylpiperazine (0.11 mL, 1.0 mmol) and potassium carbonate (0.07 g, 0.5 mmol) in 5 mL acetonitrile was added to a glass microwave reaction vessel. The reaction mixture was stirred and heated in a Smith Synthesizer® microwave reactor (Personal Chemistry, Inc., Upssala, Sweden) at 180° C. for about 20 min. After about 20 min. all starting material was converted to product (M+1=307, 309). The mixture was concentrated under vacuum and purified via flash chromatography (silica gel) eluting with a gradient of 2% 2 M ammonia in MeOH/DCM to 6% 2M ammonia in MeOH/DCM to give (0.14 g) 6-bromo-1-(4-methylpiperazin-1-yl)phthalazine as a yellow solid. Found MS (ES+): 307, 309(M+H)+.

1. additionwas added to a glass microwave reaction vessel
2. concentrationThe mixture was concentrated under vacuum
3. custompurified via flash chromatography (silica gel)
4. washeluting with a gradient of 2% 2 M ammonia in MeOH/DCM to 6% 2M ammonia in MeOH/DCM