Isopropylamine → HCID 11702889, compound

HRID 2357873Notes

Reaction equation

HRID 2357873 reaction equation
[CH:1]([NH2:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[Cl:12][C:13]1[C:18]([C:19]2[CH:24]=[C:23]([F:25])[CH:22]=[C:21]([F:26])[C:20]=2[F:27])=[C:17](Cl)[N:16]2[N:29]=[CH:30][N:31]=[C:15]2[N:14]=1>ClCCl>[Cl:12][C:13]1[C:18]([C:19]2[CH:24]=[C:23]([F:25])[CH:22]=[C:21]([F:26])[C:20]=2[F:27])=[C:17]([NH:4][CH:1]([CH3:3])[CH3:2])[N:16]2[N:29]=[CH:30][N:31]=[C:15]2[N:14]=1

Participants

5

Reactant 3

HCID 6363IsopropylamineHCID 8471TriethylamineHCID 11493446HCID 11493446, compound

Product 1

HCID 11702889HCID 11702889, compoundYield 81.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A mixture of isopropylamine (1.5 mmol), triethylamine (1.5 mmol) and dichloromethane (10 ml) was added to a mixture of 5,7-dichloro-6-(2,3,5-trifluorophenyl)-[1,2,4]-triazolo[1,5-a]pyrimidine (1.5 mmol, obtained from Ex. 3) and dichloromethane (20 ml) under stirring. The reaction mixture was stirred for 16 h. at 20 to 25° C. and washed with 5% hydrochloric acid. The organic layer was separated, dried and filtered. The filtrate was evaporated and the residue was purified by column chromatography to yield 0.42 g of the title compound of mp. 151° C.

Workup

  1. stirringThe reaction mixture was stirred for 16 h. at 20 to 25° C.
  2. washwashed with 5% hydrochloric acid
  3. customThe organic layer was separated
  4. customdried
  5. filtrationfiltered
  6. customThe filtrate was evaporated
  7. customthe residue was purified by column chromatography

Sources & evidence

ORD record
ord-17ece0df43bb474787a10b0be1920c90
Source dataset
uspto-grants-2010_07
Patent number
US07763622B2

Reaction notes

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