Hydroxyamine hydrochloride → HCID 136013274, compound

HRID 2357947Notes

Reaction equation

HRID 2357947 reaction equation
[CH:1]([C:3]1[CH:21]=[C:6]2[C:7]([C:13]3[CH:14]([CH3:20])[CH2:15][C:16](=[O:19])[NH:17][N:18]=3)=[CH:8][CH:9]=[C:10]([O:11][CH3:12])[N:5]2[N:4]=1)=O.C([O-])(=O)C.[Na+].Cl.[NH2:28][OH:29]>CO>[CH3:12][O:11][C:10]1[N:5]2[N:4]=[C:3]([CH:1]=[N:28][OH:29])[CH:21]=[C:6]2[C:7]([C:13]2[CH:14]([CH3:20])[CH2:15][C:16](=[O:19])[NH:17][N:18]=2)=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 59389278HCID 59389278, compound

Product 1

HCID 136013274HCID 136013274, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound of Example 237 (24.0 mg) was dissolved in methanol (3 mL). To this solution, sodium acetate (41.3 mg) and hydroxylamine hydrochloride (17.5 mg) were added at room temperature and the reaction mixture was stirred for 20 min. The solvent was evaporated under reduced pressure and water was added to the residue. The mixture was filtered to afford the title compound as a white powder (15.3 mg, a mixture of E-form and Z-form (E:Z=1:5)).

Workup

  1. customThe solvent was evaporated under reduced pressure and water
  2. additionwas added to the residue
  3. filtrationThe mixture was filtered

Sources & evidence

ORD record
ord-cf62664c8ae744dfbf6e8767df470a17
Source dataset
uspto-grants-2010_07
Patent number
US07763617B2

Reaction notes

Loading…