4-(3-(2,6-dimethylphenylamino)-6-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)butane-1,2-diol → 3-(3-(2,6-dimethylphenylamino)-6-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propanal

HRID 2357983Notes

Reaction equation

HRID 2357983 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[NH:9][C:10]1[C:18]2[C:13](=[N:14][C:15]([NH:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)=[N:16][CH:17]=2)[N:12]([CH2:26][CH2:27][CH:28]([OH:31])CO)[N:11]=1>CC(C)=O.O.C(Cl)Cl>[CH3:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([CH3:1])[C:3]=1[NH:9][C:10]1[C:18]2[C:13](=[N:14][C:15]([NH:19][C:20]3[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=3)=[N:16][CH:17]=2)[N:12]([CH2:26][CH2:27][CH:28]=[O:31])[N:11]=1

Participants

5

Reactant 1

HCID 160488204-(3-(2,6-dimethylphenylamino)-6-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)butane-1,2-diol

Product 1

HCID 588368773-(3-(2,6-dimethylphenylamino)-6-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)propanal

Reagents, catalysts & solvents 3

HCID 180AcetoneSolventHCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of 114 mg (0.3 mmol) of 4-(3-(2,6-dimethylphenylamino)-6-(phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)butane-1,2-diol 34 (Example 2) in 10 mL of acetone and 7 mL of water was treated with 585 mg (2.7 mmol) of NaIO4. The resulting tan slurry was stirred at room temperature for 6 h. The reaction mixture was diluted with CH2Cl2, filtered, and the filtrate was concentrated. The residue was dissolved in CH2Cl2 (75 mL) and washed with water (50 mL). The aqueous layer was extracted with more CH2Cl2 (2×75 mL). The combined organic layers were dried over Na2SO4 and filtered, and the filtrate was concentrated to give the title compound 36, which was used without further purification. 1H-NMR (CDCl3) δ 2.27 (s, 6H), 3.05 (t, J=6.7 Hz, 2H), 4.52 (t, J=6.7 Hz, 2H), 5.30 (s, 1H), 5.89 (s, 1H), 7.06 (t, J=7.6 Hz, 1H), 7.13-7.19 (m, 3H), 7.34 (t, J=7.7 Hz, 2H), 7.42 (s, 1H), 7.64 (d, J=7.7 Hz, 2H), 9.89 (s, 1H). Mass Spectrum (ESI) m/e=387.2 (M+1).

Workup

  1. filtrationfiltered
  2. concentrationthe filtrate was concentrated
  3. dissolutionThe residue was dissolved in CH2Cl2 (75 mL)
  4. washwashed with water (50 mL)
  5. extractionThe aqueous layer was extracted with more CH2Cl2 (2×75 mL)
  6. dry with materialThe combined organic layers were dried over Na2SO4
  7. filtrationfiltered
  8. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-fa1e64e7e4cb4df3bff950d9fae4529f
Source dataset
uspto-grants-2010_07
Patent number
US07763624B2

Reaction notes

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