HCID 67533082, compound → HCID 57448065, compound

HRID 2358113Notes

Reaction equation

HRID 2358113 reaction equation
[F:1][C:2]1[C:7]([S:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:10]1(O)[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]1>FC(F)(F)C(O)=O>[F:1][C:2]1[C:7]([S:8][CH3:9])=[CH:6][CH:5]=[CH:4][C:3]=1[C:10]1[CH2:15][CH2:14][NH:13][CH2:12][CH:11]=1

Participants

3

Reactant 1

HCID 67533082HCID 67533082, compound

Product 1

HCID 57448065HCID 57448065, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Preparation according to preparation 2: Tert-butyl 4-[2-fluoro-3-(methylthio)-phenyl]-4-hydroxy-piperidine-1-carboxylate (2.0 g, 5.86 mmol), trifluoroacetic acid (20 ml). Yield: 1.42 g. MS m/z (rel. intensity, 70 eV) 223 (M+, bp), 222 (32), 147 (61), 146 (47), 133 (27).

Workup

  1. customPreparation
  2. customaccording to preparation 2

Sources & evidence

ORD record
ord-4aa1ad7356fe4a7dbfca4c236d755b37
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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