Iodoethane → HCID 67533166, compound

HRID 2358132Notes

Reaction equation

HRID 2358132 reaction equation
[F:1][C:2]1[C:7]([C:8]2([CH3:13])[O:12][CH2:11][CH2:10][O:9]2)=[CH:6][CH:5]=[CH:4][C:3]=1[C:14]1[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=1.I[CH2:21][CH3:22].[BH4-].[Na+]>C(O)C>[CH2:21]([N:17]1[CH2:16][CH:15]=[C:14]([C:3]2[CH:4]=[CH:5][CH:6]=[C:7]([C:8]3([CH3:13])[O:9][CH2:10][CH2:11][O:12]3)[C:2]=2[F:1])[CH2:19][CH2:18]1)[CH3:22]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 4311764Sodium borohydrideHCID 57448072HCID 57448072, compound

Product 1

HCID 67533166HCID 67533166, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Preparation according to preparation 6: 4-[2-fluoro-3-(2-methyl-1,3-dioxolan-2-yl)phenyl]pyridine (0.95 g, 3.66 mmol), 1-iodoethane (4 ml), ethanol (40 ml), sodium borohydride (1.0 g, 29.3 mmol). Yield: 0.88 g. MS m/z (rel. intensity, 70 eV) 291 (M+, bp), 276 (94), 219 (29), 110 (46), 87 (29).

Workup

  1. customPreparation
  2. customaccording to preparation 6

Sources & evidence

ORD record
ord-bf389f5036914b9f965267f2df9d4768
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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