Hydrochloric Acid → HCID 67532664, compound

HRID 2358146Notes

Reaction equation

HRID 2358146 reaction equation
[F:1][C:2]([F:19])([F:18])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[C:6]=1[F:17])=[O:4].Cl>[Pt]=O.CO>[F:19][C:2]([F:1])([F:18])[C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[C:6]=1[F:17])=[O:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57448077Ethanone, 2,2,2-trifluoro-1-[2-fluoro-3-(4-pyridinyl)phenyl]-

Product 1

HCID 67532664HCID 67532664, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

Preparation according to preparation 9: 2,2,2-trifluoro-1-(2-fluoro-3-pyridin-4-ylphenyl)ethanone (1.26 g, 4.68 mmol), hydrochloric acid (0.2 ml, conc), methanol (20 ml), platinum oxide (0.12 g). Yield: 0.98 g. MS m/z (relative intensity, 70 eV) 275 (M+, 94), 274 (66), 149 (23), 101 (25) 56 (bp).

Workup

  1. customPreparation
  2. customaccording to preparation 9

Sources & evidence

ORD record
ord-21c8edf354854b9eadd5076346ef6536
Source dataset
uspto-grants-2010_07
Patent number
US07763639B2

Reaction notes

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