Potassium Carbonate → HCID 58911267, compound

HRID 2358238Notes

Reaction equation

HRID 2358238 reaction equation
Br[CH2:2][CH2:3][CH2:4][C:5]([NH:7][C:8]1([N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH2:10][CH2:9]1)=[O:6].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[N:11]1([C:8]2([N:7]3[CH2:2][CH2:3][CH2:4][C:5]3=[O:6])[CH2:10][CH2:9]2)[CH:15]=[CH:14][N:13]=[CH:12]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 58911254HCID 58911254, compound

Product 1

HCID 58911267HCID 58911267, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a 50 ml three necked flask fitted with a magnetic stirrer, under inert atmosphere, the crude 4-bromo-N-(1-imidazol-1-yl-cyclopropyl)-butyramide a18 (2.76 g), K2CO3 (1.26 g, 9.1 mmol) and KI (0.0075 g) in DMF (25 ml) are heated 3 h at 60° C., 17 h at 80° C., cooled down to room temperature and concentrated in vacuo. The reaction mixture is diluted with CH2Cl2, filtered and concentrated in vacuo to give the crude pyrrolidone (1.7 g). The residue is purified by chromatography on silicagel (CH2Cl2/MeOH/NH4OH: 95/4.5/05 (v/v/v)) to give, after treatment with HCl in ether (1 eq) and recrystallization in MeCN, 1-[1-(1H-imidazol-1-yl)cyclopropyl]pyrrolidin-2-one 23 (0.033 g, 7.5%) as an hydrochloride.

Workup

  1. concentrationconcentrated in vacuo
  2. additionThe reaction mixture is diluted with CH2Cl2
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-132f9b380e8d4a308621aa76b1652283
Source dataset
uspto-grants-2010_07
Patent number
US07763644B2

Reaction notes

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