Cyclopentanecarbaldehyde → HCID 58000835, compound

HRID 2358259Notes

Reaction equation

HRID 2358259 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[C:9]([C:12]2C=C[N:15]=[C:14](F)[CH:13]=2)=[N:10][OH:11])=[CH:4][CH:3]=1.[CH:20]1([CH:25]=O)[CH2:24][CH2:23][CH2:22][CH2:21]1.[C:27]([O-:30])(=O)[CH3:28].[NH4+:31]>C(O)(=O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:31]=[C:25]([CH:20]3[CH2:21][CH2:22][CH2:23][CH2:24]3)[N:10]([OH:11])[C:9]=2[C:12]2[CH:13]=[CH:14][NH:15][C:27](=[O:30])[CH:28]=2)=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 70106CyclopentanecarbaldehydeHCID 517165Ammonium AcetateHCID 136355272HCID 136355272, compound

Product 1

HCID 58000835HCID 58000835, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Using the general procedure found in Example 1 Step C, the intermediate from Example 1 Step B was combined with cyclopentane carboxaldehyde and ammonium acetate and acetic acid. 1H NMR (400 MHz, DMSO-d6): δ11.95 (br, 2H), 7.35˜7.70 (m, 8H), 6.45 (m, 1H), 6.15 (m, 1H).

Sources & evidence

ORD record
ord-6fedcf36b40349959ab752617da3df8c
Source dataset
uspto-grants-2010_07
Patent number
US07763634B2

Reaction notes

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