Trifluoroacetic acid → HCID 57665528, compound

HRID 2358372Notes

Reaction equation

HRID 2358372 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:15]=[CH2:16])[C:12]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])=[C:11]([F:22])[CH:10]=1)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:15]=[CH2:16])[C:12]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])=[C:11]([F:22])[CH:10]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68455779HCID 68455779, compound

Product 1

HCID 57665528HCID 57665528, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

(3-fluoro-4-methanesulfonylamino-5-vinyl-benzyl)-carbamic acid t-butyl ester (1 ml) was put into 25 ml round-bottom flask and dissolved in methylenechloride. To the solution was added trifluoroacetic acid (1 ml) and stirred for one night. After confirming the completion of the reaction with TLC, the reaction solution was concentrated under reduced pressure to yield a brown crude liquid (236.7 mg).

Workup

  1. customthe completion of the reaction with TLC
  2. concentrationthe reaction solution was concentrated under reduced pressure

Sources & evidence

ORD record
ord-b51e80f440ac4c49b7d36a92d704cf26
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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