HCID 68456052, compound → HCID 68453767, compound

HRID 2358378Notes

Reaction equation

HRID 2358378 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:15]=[CH2:16])[C:12]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])=[C:11]([CH3:22])[CH:10]=1)(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:15]=[CH2:16])[C:12]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])=[C:11]([CH3:22])[CH:10]=1

Participants

4

Reactant 1

HCID 68456052HCID 68456052, compound

Product 1

HCID 68453767HCID 68453767, compoundYield 464.2%

Reagents, catalysts & solvents 2

HCID 6422Trifluoroacetic acidCatalystHCID 6344DichloromethaneSolvent

Procedure

(4-Methanesulfonylamino-3-methyl-5-vinylbenzyl)carbamic acid tert-butyl ester (85.9 mg, 0.09 mmol) was dissolved in CH2Cl2. 5˜6 drops of CF3COOH were added. The reaction mixture was stirred for 12 hr. The reaction mixture was concentrated to yield brownish syrup (100.4 mg).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-d88bf5b4e4a34bb588b68b8299c0a1f4
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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