HCID 68455313, compound → N-(4-Aminomethyl-2-trifluoromethyl-6-vinylphenyl)methanesulfonamide

HRID 2358391Notes

Reaction equation

HRID 2358391 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:15]=[CH2:16])[C:12]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])=[C:11]([C:22]([F:25])([F:24])[F:23])[CH:10]=1)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:7][CH2:8][C:9]1[CH:14]=[C:13]([CH:15]=[CH2:16])[C:12]([NH:17][S:18]([CH3:21])(=[O:20])=[O:19])=[C:11]([C:22]([F:25])([F:23])[F:24])[CH:10]=1

Participants

4

Reactant 1

HCID 68455313HCID 68455313, compound

Product 1

HCID 68453783N-(4-Aminomethyl-2-trifluoromethyl-6-vinylphenyl)methanesulfonamideYield 149.8%

Reagents, catalysts & solvents 2

HCID 6422Trifluoroacetic acidCatalystHCID 6344DichloromethaneSolvent

Procedure

(4-Methanesulfonylamino-3-trifluoromethyl-5-vinylbenzyl)carbamic acid tert-butyl ester (89.3 mg, 0.23 mmol) and CF3COOH (5˜6 drops) were added into methylene chloride. The mixture was stirred for 12 hr. The reaction mixture was purified according to step 6 of Example 8 to give a title product (101.4 mg, 100%).

Workup

  1. customThe reaction mixture was purified

Sources & evidence

ORD record
ord-dae93424595a4958a0a1ff9cfab68020
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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