Hydrochloric Acid → HCID 68455970, compound

HRID 2358403Notes

Reaction equation

HRID 2358403 reaction equation
C[O:2][C:3](=[O:20])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:8][C:7]=1[NH:16][CH:17]([CH3:19])[CH3:18].[OH-].[Na+].Cl>CO.O>[C:12]([C:9]1[CH:10]=[CH:11][C:6]([CH:5]=[CH:4][C:3]([OH:20])=[O:2])=[C:7]([NH:16][CH:17]([CH3:19])[CH3:18])[CH:8]=1)([CH3:15])([CH3:13])[CH3:14]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 68456145HCID 68456145, compound

Product 1

HCID 68455970HCID 68455970, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

3-(4-tert-butyl-2-isopropylaminophenyl)acrylic acid methyl ester (0.14 mmol, 37.7 mg) and NaOH (0.68 mmol, 27.39 mg) were added in methanol and water. The reaction mixture was stirred for 12 hrs at room temperature. The reaction mixture was acidified with 5% HCl solution. The mixture was concentrated in vacuo to yield a yellow solid (36.56 mg, 100%).

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-bd9b241196d74ba59c07b71b2ec756b8
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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