Trifluoroacetic acid → N-(4-aminomethyl-2-vinylphenyl)methanesulfonamide

HRID 2358413Notes

Reaction equation

HRID 2358413 reaction equation
[CH3:1][S:2]([NH:5][C:6]1[CH:20]=[CH:19][C:9]([CH2:10][NH:11]C(=O)OC(C)(C)C)=[CH:8][C:7]=1[CH:21]=[CH2:22])(=[O:4])=[O:3].C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:11][CH2:10][C:9]1[CH:19]=[CH:20][C:6]([NH:5][S:2]([CH3:1])(=[O:4])=[O:3])=[C:7]([CH:21]=[CH2:22])[CH:8]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68453842tert-butyl N-[4-(methanesulfonylamino)-3-vinylbenzyl]carbamate

Product 1

HCID 57665523N-(4-aminomethyl-2-vinylphenyl)methanesulfonamideYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-butyl N-[4-(methanesulfonylamino)-3-vinylbenzyl]carbamate (100 mg, 0.23 mmol) and TFA (0.4 ml) were added in methylene chloride (2 mL). The reaction mixture was stirred overnight at room temperature. The reaction mixture was concentrated in vacuo to yield title compound (100%).

Workup

  1. concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-4526187acada425ca43e0ba34d9fc053
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

Loading…