Hydrochloric Acid → 3-(4-tert-butyl-phenyl)-N-(4-methanesulfonylamino-3-vinyl-benzyl)-2-phenyl-acrylamide

HRID 2358424Notes

Reaction equation

[CH3:1][S:2]([NH:5][C:6]1[CH:13]=[CH:12][C:9]([CH2:10][NH2:11])=[CH:8][C:7]=1[CH:14]=[CH2:15])(=[O:4])=[O:3].Cl.[C:17]([C:21]1[CH:26]=[CH:25][C:24]([CH:27]=[C:28]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:29](O)=[O:30])=[CH:23][CH:22]=1)([CH3:20])([CH3:19])[CH3:18]>>[C:17]([C:21]1[CH:26]=[CH:25][C:24]([CH:27]=[C:28]([C:32]2[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=2)[C:29]([NH:11][CH2:10][C:9]2[CH:12]=[CH:13][C:6]([NH:5][S:2]([CH3:1])(=[O:4])=[O:3])=[C:7]([CH:14]=[CH2:15])[CH:8]=2)=[O:30])=[CH:23][CH:22]=1)([CH3:20])([CH3:18])[CH3:19]

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 57665523N-(4-aminomethyl-2-vinylphenyl)methanesulfonamide

HCID 684536973-(4-tert-Butyl-phenyl)-2-phenyl-acrylic Acid

Product 1

HCID 684561383-(4-tert-butyl-phenyl)-N-(4-methanesulfonylamino-3-vinyl-benzyl)-2-phenyl-acrylamideYield 46%

Procedure

4-Methanesulfonylamino-3-vinyl-benzylamine and HCl salt (153 mg, 0.582 mmol) were reacted with 3-(4-tert-butyl-phenyl)-2-phenyl-acrylic acid (160.4 mg) to give 3-(4-tert-butyl-phenyl)-N-(4-methanesulfonylamino-3-vinyl-benzyl)-2-phenyl-acrylamide (130.8 mg, 46%).

Sources & evidence

ORD record: ord-2cbc6ed1ff7e49769577e7790ccf153a
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07763657B2

Reaction notes

Loading…