Trifluoroacetic acid → HCID 68457029, compound

HRID 2358433Notes

Reaction equation

HRID 2358433 reaction equation
C(OC(=O)[NH:7][CH:8]([C:10]1[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH:20]=[CH2:21])(=[O:19])=[O:18])=[C:12]([CH:22]=[CH2:23])[CH:11]=1)[CH3:9])(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:20]([S:17]([NH:16][C:13]1[CH:14]=[CH:15][C:10]([CH:8]([NH2:7])[CH3:9])=[CH:11][C:12]=1[CH:22]=[CH2:23])(=[O:18])=[O:19])=[CH2:21]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 76587252HCID 76587252, compound

Product 1

HCID 68457029HCID 68457029, compoundYield 154.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[1-(4-Ethenesulfonylamino-3-vinyl-phenyl)-ethyl]-carbamic acid tert-butyl ester (20.0 mg, 0.04 mmol) and CF3COOH (5 eq, 0.22 mmol, 17.04 μl) were dissolved in methylene chloride. The reaction mixture was stirred for 12 hrs. A reaction mixture was concentrate to yield [1-(4-Ethenesulfonylamino-3-vinyl-phenyl)-ethylamine (15.6 mg, 76%).

Workup

  1. concentrationA reaction mixture was concentrate

Sources & evidence

ORD record
ord-4a7fd58791064a65b27fa97eb4b8726c
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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