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HRID2358436

反应详情

EQUATION

反应方程式

HRID 2358436 的结构方程式

REACTANTS

反应物

2
结构：O=C(O)C(F)(F)F
HCID6422

未命名化合物

结构：CC(NC(=O)OC(C)(C)C)c1ccc(NS(C)(=O)=O)c(C#Cc2ccccc2)c1
HCID76587256

未命名化合物

PRODUCTS

生成物

1
结构：CC(N)c1ccc(NS(C)(=O)=O)c(C#Cc2ccccc2)c1
HCID68456794

未命名化合物

收率 193.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

[1-(4-Methanesulfonylamino-3-phenylethynylphenyl)ethyl]carbamic acid tert-butyl ester (300 mg, 0.724 mmol) and trifluoroacetic acid (279 μl, 3.619 mmol, 3 eq) were added in methylene chloride. The reaction mixture was stirred for 24 hrs. A reaction solvent was removed in vacuo to yield 1-(4-methanesulfonylamino-3-phenylethynylphenyl)ethylamine (440.1 mg, 100%).

WORKUP

后处理

  1. customA reaction solvent was removed in vacuo