Iodoethane → 2-Butyl-6-(2,5-dimethyl-pyrrol-1-yl)-pyridine

HRID 2358573Notes

Reaction equation

[CH3:1][C:2]1[N:3]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[N:9]=2)[C:4]([CH3:7])=[CH:5][CH:6]=1.[CH2:15](I)[CH2:16][CH3:17].C(I)C>>[CH2:14]([C:10]1[CH:11]=[CH:12][CH:13]=[C:8]([N:3]2[C:2]([CH3:1])=[CH:6][CH:5]=[C:4]2[CH3:7])[N:9]=1)[CH2:15][CH2:16][CH3:17]

Participants

Reactant 3

HCID 6340Iodoethane

HCID 336431-Iodopropane

HCID 7931562-(2,5-Dimethyl-1H-pyrrol-1-yl)-6-methylpyridine

Product 1

HCID 133983052-Butyl-6-(2,5-dimethyl-pyrrol-1-yl)-pyridineYield 64.4%

Procedure

The product from Example 2a 1.0 g, 5.37 mmol) was reacted with propyl iodide 0.55 mL, 5.64 mmol) in place of ethyl iodide following the procedure from Example 2b to give the title compound (790 mg, 64%).

Sources & evidence

ORD record: ord-89d09835880d42a8a45f27d8d01f4814
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07763731B2

Reaction notes

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