2-Amino-4-methylphenol → HCID 68461887, compound

HRID 2358659Notes

Reaction equation

HRID 2358659 reaction equation
Cl[C:2]1[CH:11]=[CH:10][N:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:12])=[N:7]2.[NH2:13][C:14]1[CH:19]=[C:18]([CH3:20])[CH:17]=[CH:16][C:15]=1[OH:21]>C(O)C>[CH3:20][C:18]1[CH:17]=[CH:16][C:15]([OH:21])=[C:14]([NH:13][C:2]2[C:3]3[C:8](=[N:7][C:6]([CH3:12])=[CH:5][CH:4]=3)[N:9]=[CH:10][CH:11]=2)[CH:19]=1

Participants

4

Reactant 2

HCID 72642-Amino-4-methylphenolHCID 122663725-Chloro-2-methyl-1,8-naphthyridine

Product 1

HCID 68461887HCID 68461887, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The product from Example 1d (893 mg, 5 mmol) and 2-Amino-4-methyl-phenol (616 mg, 5 mmol) in ethanol (20 mL) were refluxed for 4 hours. The mixture was cooled to room temperature and evaporated. The residue was triturated with hexane/ethyl acetate (3:1) to give the title compound in quantitative yield as the hydrochloride salt.

Workup

  1. customevaporated
  2. customThe residue was triturated with hexane/ethyl acetate (3:1)

Sources & evidence

ORD record
ord-fe08ef76e90f4c1991afd4808eac834b
Source dataset
uspto-grants-2010_07
Patent number
US07763731B2

Reaction notes

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