Phosphorus oxychloride → HCID 13773146, compound

HRID 235872Notes

Reaction equation

HRID 235872 reaction equation
[C:1]([NH:6][CH:7]([C:14]([C:16]1[O:17][CH:18]=[CH:19][CH:20]=1)=[O:15])[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])(=O)[CH:2]([CH3:4])[CH3:3].P(Cl)(Cl)(Cl)=O>C(Cl)(Cl)Cl>[CH:2]([C:1]1[O:15][C:14]([C:16]2[O:17][CH:18]=[CH:19][CH:20]=2)=[C:7]([CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[N:6]=1)([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 13773137HCID 13773137, compound

Product 1

HCID 13773146HCID 13773146, compoundYield 89.2%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

12.0 g of ethyl 3-isobutyrylamino-3-(2-furylcarbonyl)propionate, 60 ml of chloroform and 32.7 g of phosphorus oxychloride are treated in the same manner as described in Example 2. 10.0 g of ethyl 2-[2-isopropyl-5-(2-furyl)-4-oxazolyl]acetate are thereby obtained as an oil. Yield: 89.2%

Sources & evidence

ORD record
ord-d01b574f2b3e490e99aa4f46111ce121
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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