反应详情

The product from Example 221b (0.16 g, 0.52 mmol) was reacted with 90% 4-mercapto-phenol (0.073 g, 0.52 mmol) in DMF at 80° C. under nitrogen in the presence of potassium carbonate (0.126 g, 0.91 mmol). The reaction was quenched after 18 h by pouring into dilute HCl and extraction with ether. The combined extracts were dried over MgSO4, filtered and concentrated under vacuum giving the crude title compound. The crude product was purified by flash chromatography on silica gel eluting with EtOAc-hexanes to give the title compound (0.155 g, 84%).

1. customThe reaction was quenched after 18 h
2. additionby pouring into dilute HCl and extraction with ether
3. dry with materialThe combined extracts were dried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated under vacuum
6. customgiving the crude title compound
7. customThe crude product was purified by flash chromatography on silica gel eluting with EtOAc-hexanes