Ethyl bromoacetate → HCID 13773131, compound

HRID 235891Notes

Reaction equation

[Cl:1][C:2]1[CH:18]=[CH:17][C:5]([C:6]([NH:8][CH2:9][C:10]([C:12]2[CH:16]=[CH:15][O:14][CH:13]=2)=[O:11])=[O:7])=[CH:4][CH:3]=1.[H-].[Na+].Br[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH:9]([C:10]([C:12]2[CH:16]=[CH:15][O:14][CH:13]=2)=[O:11])[CH2:22][C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:7])=[CH:17][CH:18]=1

Participants

Reactant 3

HCID 7748Ethyl bromoacetate

HCID 24758Sodium hydride

HCID 137731224-Chloro-N-[2-(furan-3-yl)-2-oxoethyl]benzamide

Product 1

HCID 13773131HCID 13773131, compoundYield 77.3%

Procedure

8.3 g of N-(4-chlorobenzoyl)-(3-furylcarbonyl)methylamine, 1.5 g of 61% sodium hydride and 5.8 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(2). 8.5 g of ethyl 3-(4-chlorobenzoylamino)-3-(3-furylcarbonyl)propionate are thereby obtained. Yield: 77.3%

Workup

customas described in Preparation 1-(2)

Sources & evidence

ORD record: ord-df81bac86a9f487f9cf97540113d17b7
Source dataset: uspto-grants-1987_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04642313

Reaction notes

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