4-Fluorobenzoyl chloride → 4-Fluoro-N-[2-(furan-2-yl)-2-oxoethyl]benzamide

HRID 235894Notes

Reaction equation

HRID 235894 reaction equation
Cl.[O:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([CH2:9][NH2:10])=[O:8].C(=O)(O)[O-].[Na+].[F:16][C:17]1[CH:25]=[CH:24][C:20]([C:21](Cl)=[O:22])=[CH:19][CH:18]=1>>[F:16][C:17]1[CH:25]=[CH:24][C:20]([C:21]([NH:10][CH2:9][C:7]([C:3]2[O:2][CH:6]=[CH:5][CH:4]=2)=[O:8])=[O:22])=[CH:19][CH:18]=1

Participants

4

Reactant 3

HCID 678794-Fluorobenzoyl chlorideHCID 516892Sodium BicarbonateHCID 132261382-Amino-1-(furan-2-yl)ethan-1-one--hydrogen chloride (1/1)

Product 1

HCID 134707334-Fluoro-N-[2-(furan-2-yl)-2-oxoethyl]benzamideYield 67%

Procedure

23.4 g of (2-furylcarbonyl)methylamine hydrochloride, 29.3 g of sodium bicarbonate and 23.0 g of 4-fluorobenzoyl chloride are treated in the same manner as described in Preparation 1-(1). 24.0 g of N-(4-fluorobenzoyl)-(2-furylcarbonyl)methylamine are thereby obtained. Yield: 66.8%

Workup

  1. customas described in Preparation 1-(1)

Sources & evidence

ORD record
ord-be7d3b4d25604a049b6409e91e38003e
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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