p-Anisoyl chloride → N-[2-(Furan-2-yl)-2-oxoethyl]-4-methoxybenzamide

HRID 235898Notes

Reaction equation

HRID 235898 reaction equation
Cl.[O:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([CH2:9][NH2:10])=[O:8].C(=O)(O)[O-].[Na+].[CH3:16][O:17][C:18]1[CH:26]=[CH:25][C:21]([C:22](Cl)=[O:23])=[CH:20][CH:19]=1>>[CH3:16][O:17][C:18]1[CH:26]=[CH:25][C:21]([C:22]([NH:10][CH2:9][C:7]([C:3]2[O:2][CH:6]=[CH:5][CH:4]=2)=[O:8])=[O:23])=[CH:20][CH:19]=1

Participants

4

Reactant 3

HCID 7477p-Anisoyl chlorideHCID 516892Sodium BicarbonateHCID 132261382-Amino-1-(furan-2-yl)ethan-1-one--hydrogen chloride (1/1)

Product 1

HCID 13773125N-[2-(Furan-2-yl)-2-oxoethyl]-4-methoxybenzamideYield 85.7%

Procedure

8.0 g of (2-furylcarbonyl)methylamine hydrochloride, 10.5 g of sodium bicarbonate and 10.1 g of 4-methoxybenzoyl chloride are treated in the same manner as described in Preparation 1-(1). 11.0 g of N-(4-methoxybenzoyl)-(2-furylcarbonyl)methylamine are thereby obtained. Yield: 85.3%

Workup

  1. customas described in Preparation 1-(1)

Sources & evidence

ORD record
ord-83a2138b48e3480a84e1c9e011dca921
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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