Ethyl bromoacetate → HCID 13773135, compound

HRID 235899Notes

Reaction equation

HRID 235899 reaction equation
[CH3:1][O:2][C:3]1[CH:19]=[CH:18][C:6]([C:7]([NH:9][CH2:10][C:11]([C:13]2[O:14][CH:15]=[CH:16][CH:17]=2)=[O:12])=[O:8])=[CH:5][CH:4]=1.[H-].[Na+].Br[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:9][CH:10]([C:11]([C:13]2[O:14][CH:15]=[CH:16][CH:17]=2)=[O:12])[CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[O:8])=[CH:18][CH:19]=1

Participants

4

Reactant 3

HCID 7748Ethyl bromoacetateHCID 24758Sodium hydrideHCID 13773125N-[2-(Furan-2-yl)-2-oxoethyl]-4-methoxybenzamide

Product 1

HCID 13773135HCID 13773135, compoundYield 73%

Procedure

11.0 g of N-(4-methoxybenzoyl)-(2-furylcarbonyl)methylamine, 2.0 g of 61% sodium hydride and 7.8 g of ethyl bromoacetate are treated in the same manner ad described in Preparation 1-(2). 10.7 g of ethyl 3-(4-methoxybenzoylamino)-3-(2-furylcarbonyl)propionate are thereby obtained. Yield: 72.8%

Workup

  1. customdescribed in Preparation 1-(2)

Sources & evidence

ORD record
ord-e36c041459a647d690d9fbad03c56f0d
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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