Ethyl bromoacetate → HCID 13773137, compound

HRID 235902Notes

Reaction equation

[C:1]([NH:6][CH2:7][C:8]([C:10]1[O:11][CH:12]=[CH:13][CH:14]=1)=[O:9])(=[O:5])[CH:2]([CH3:4])[CH3:3].[H-].[Na+].Br[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[C:1]([NH:6][CH:7]([C:8]([C:10]1[O:11][CH:12]=[CH:13][CH:14]=1)=[O:9])[CH2:18][C:19]([O:21][CH2:22][CH3:23])=[O:20])(=[O:5])[CH:2]([CH3:4])[CH3:3]

Participants

Reactant 3

HCID 7748Ethyl bromoacetate

HCID 24758Sodium hydride

HCID 13773127N-[2-(Furan-2-yl)-2-oxoethyl]-2-methylpropanamide

Product 1

HCID 13773137HCID 13773137, compoundYield 64.2%

Procedure

13.0 g of N-isobutyryl-(2-furylcarbonyl)methylamine, 3.1 g of 61% sodium hydride and 12.2 g of ethyl bromoacetate are treated in the same manner as described in Preparation 1-(2). 12.0 g of ethyl 3-isobutyrylamino-3-(2-furylcarbonyl)propionate are thereby obtained. Yield: 64.2%

Workup

customas described in Preparation 1-(2)

Sources & evidence

ORD record: ord-bf03fb0af5f543b69128c618eb51726c
Source dataset: uspto-grants-1987_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04642313

Reaction notes

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