反应详情

A mixture of 1-(5-chloro-2-thienyl)-3-(dimethylamino)-2-(pyridin-4-yl)prop-2-en-1-one (5.1 mmol), hydrazine hydrate (7.6 mmol) and triethylamine (7.6 mmol) in 25 mL ethanol was refluxed for 3 h. The solvent was evaporated under reduced pressure and the residue was purified by chromatography on silica gel (dichloromethane:methanol 50:1 to 20:1) to afford 1.16 g 4-[3-(5-chloro-2-thienyl)-1H-pyrazol-4-yl]pyridine (83% yield).

1. temperaturewas refluxed for 3 h
2. customThe solvent was evaporated under reduced pressure
3. customthe residue was purified by chromatography on silica gel (dichloromethane:methanol 50:1 to 20:1)