Hydrazine hydrate (1:1) → HCID 178477882, compound

HRID 2359028Notes

Reaction equation

HRID 2359028 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7](=O)[C:8]([C:13]2[CH:18]=[CH:17][N:16]=[C:15]([Cl:19])[CH:14]=2)=[CH:9][N:10](C)C)=[CH:4][CH:3]=1.O.[NH2:22]N>C(O)C>[Cl:19][C:15]1[CH:14]=[C:13]([C:8]2[C:7]([C:5]3[S:6][C:2]([Cl:1])=[CH:3][CH:4]=3)=[N:22][NH:10][CH:9]=2)[CH:18]=[CH:17][N:16]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 86657917HCID 86657917, compound

Product 1

HCID 178477882HCID 178477882, compoundYield 101.3%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
80 °C

Procedure

A mixture of 1-(5-chloro-2-thienyl)-3-(dimethylamino)-2-(2-chloropyridin-4-yl)prop-2-en-1-one (10 mmol), hydrazine hydrate (20 mmol) in 90 mL ethanol was stirred at 80° C. for 1.5 h. The solvent was evaporated under reduced pressure to afford 3 g 2-chloro-4-[3-(5-chloro-2-thienyl)-1H-pyrazol-4-yl]pyridine (95% yield).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-c2f7b834a2f547ad82c6bcc26dd8831e
Source dataset
uspto-grants-2014_04
Patent number
US08685974B2

Reaction notes

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