Cyclohexanecarbonyl chloride → N-[2-(Furan-2-yl)-2-oxoethyl]cyclohexanecarboxamide

HRID 235903Notes

Reaction equation

Cl.[O:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([CH2:9][NH2:10])=[O:8].C(=O)(O)[O-].[Na+].[CH:16]1([C:22](Cl)=[O:23])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[CH:16]1([C:22]([NH:10][CH2:9][C:7]([C:3]2[O:2][CH:6]=[CH:5][CH:4]=2)=[O:8])=[O:23])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

Reactant 3

HCID 75938Cyclohexanecarbonyl chloride

HCID 516892Sodium Bicarbonate

HCID 132261382-Amino-1-(furan-2-yl)ethan-1-one--hydrogen chloride (1/1)

Product 1

HCID 13773128N-[2-(Furan-2-yl)-2-oxoethyl]cyclohexanecarboxamideYield 91.5%

Procedure

5.0 g of (2-furylcarbonyl)methylamine hydrochloride, 7.6 g of sodium bicarbonate and 4.8 g of cyclohexylcarbonyl chloride are treated in the same manner as described in Preparation 1-(1). 6.5 g of N-cyclohexylcarbonyl-(2-furylcarbonyl)methylamine are thereby obtained. Yield: 91.5%

Workup

customas described in Preparation 1-(1)

Sources & evidence

ORD record: ord-f2c5f92bd3a04fc38d078a79145b0a51
Source dataset: uspto-grants-1987_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04642313

Reaction notes

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