反应详情

温度

80 °C

N-Bromosuccinimide (1 eq, 0.38 mmol) was added to a solution of 4-[3-(5-chloro-2-thienyl)-1H-pyrazol-4-yl]pyridine (1 eq, 0.38 mmol) in 2 mL of N,N-dimethylformamide. The mixture was then stirred at 80° C. for 2 h. Further N-Bromosuccinimide (0.3 eq, 0.12 mmol) was added and the mixture was stirred for one more hour. After cooling to room temperature, ethyl acetate was added and the organic layer was washed with water, dried over MgSO4, filtered and evaporated. The residue was suspended in diisopropylether and dichloropethane, filtered and dried in a vacuum oven at 50° C. to afford 0.16 g of 4-[5-bromo-3-(5-chloro-2-thienyl)-1H-pyrazol-4-yl]pyridine.

1. stirringthe mixture was stirred for one more hour
2. temperatureAfter cooling to room temperature
3. washthe organic layer was washed with water
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customevaporated
7. filtrationdichloropethane, filtered
8. customdried in a vacuum oven at 50° C.