Benzoyl chloride → N-[2-(Furan-3-yl)-2-oxoethyl]benzamide

HRID 235907Notes

Reaction equation

HRID 235907 reaction equation
Cl.[O:2]1[CH:6]=[CH:5][C:4]([C:7]([CH2:9][NH2:10])=[O:8])=[CH:3]1.C(=O)(O)[O-].[Na+].[C:16](Cl)(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:16]([NH:10][CH2:9][C:7]([C:4]1[CH:5]=[CH:6][O:2][CH:3]=1)=[O:8])(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 3

HCID 7412Benzoyl chlorideHCID 516892Sodium BicarbonateHCID 137731212-Amino-1-(furan-3-yl)ethan-1-one--hydrogen chloride (1/1)

Product 1

HCID 13773129N-[2-(Furan-3-yl)-2-oxoethyl]benzamideYield 91.8%

Procedure

6.0 g of (3-furylcarbonyl)methylamine hydrochloride, 7.8 g of sodium bicarbonate and 5.7 g of benzoyl chloride are treated in the same manner as described in Preparation 1-(1). 7.8 g of N-benzoyl-(3-furylcarbonyl)methylamine are thereby obtained. Yield: 91.8%

Workup

  1. customas described in Preparation 1-(1)

Sources & evidence

ORD record
ord-9c2894dd6ef646048673f0d55cc00d38
Source dataset
uspto-grants-1987_02
Patent number
US04642313

Reaction notes

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